4-[4-氯-1-丁酰基]-A,A-二甲基苯乙酸甲酯合成路线 （共 30 条）
反应条件
1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C 2: hydrogenchloride; methanol / 7 h / 40 - 45 °C View Scheme
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 160 - 165 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Inert atmosphere 2.2: 0 °C / Inert atmosphere 3.1: sodium hydroxide; methanol / 2 h / 20 °C 4.1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C 5.1: hydrogenchloride; methanol / 7 h / 40 - 45 °C View Scheme
反应条件
1: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 2: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating 3: 67.6 percent / NaOH; MeOH / 2 h / Heating View Scheme
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 72 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Example 103 ;
反应条件
potassium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide); isobutyl methylketone T=120°C; 18 h;
参考文献
MATRIX LABORATORIES LIMITED
Patent: WO2009/136412 A2, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 30 - 40 h; Heating / reflux; Product distribution / selectivity;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; MERWADE, Aravind, Yekanathsa; KHAN, Anjum, Reyaz; SOLANKI, Pawan, Vrajlal
Patent: WO2007/7347 A1, 2007 ;
Location in patent: Page/Page column 4-5; 8; 11-12 ;
反应条件
1: sulfuric acid / methanol / 3 h / |Reflux 2: potassium iodide; sodium hydrogencarbonate / toluene; water / 15 h / |Reflux 3: sulfuric acid; water / methanol / 12 h / 40 °C View Scheme
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
反应条件
1: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 2: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating View Scheme
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
in toluene 29 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 103-104 ;
反应条件
hydrogenchloride in methanol; water T=10 - 20°C; 24 h;
参考文献
CIPLA LIMITED; WAIN, Christopher, Paul
Patent: WO2005/19175 A1, 2005 ;
Location in patent: Page/Page column 25 ;
