4-(4-羟基联苯甲基)哌啶-1-氧代丁基-2,2-二甲基苯乙酸甲酯合成路线 （共 20 条）
反应条件
1: With toluene-4-sulfonic acid; PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in ethanol T=20°C; 48 h; 2: With sodium hydrogencarbonate in ethyl acetate pH=10 - 11;
参考文献
DIPHARMA FRANCIS S.r.I.
Patent: US2010/228034 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
ZnF2; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=80°C; 2 h;
参考文献
AMR Technology, Inc.
Patent: US2006/63808 A1, 2006 ;
Location in patent: Page/Page column 8; 10; 14 ;
反应条件
potassium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide); isobutyl methylketone T=120°C; 18 h;
参考文献
WO2005/19175 A1, ;
Page/Page column 26 ;
反应条件
magnesium sulfate in acetone
参考文献
Schroeder, Collin; Huddleston, Ryan; Charles, Richard
Patent: US2003/105329 A1, 2003 ;
反应条件
sulfuric acid; water in methanol T=40°C; 12 h;
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
Location in patent: Paragraph 0114 ;
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 72 h;
参考文献
US6348597 B2, ;
Page column 98-99 ;
反应条件
sodium hydrogencarbonate; potassium iodide in water; toluene 20 h; Reflux;
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
Location in patent: Paragraph 0106 ;
反应条件
water; potassium carbonate in methanol T=20 - 40°C; 16 - 26 h; Product distribution / selectivity;
参考文献
WO2007/135693 A2, ;
Page/Page column 14-15: 18 ;
反应条件
1: 97 percent / Et3N / tetrakis(triphenylphosphine)palladium(0), Cu2Br2 / 3.5 h / Heating 2: 100 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 3: 75 percent / K2CO3 / acetonitrile / 12 h / Heating 4: 75 percent / HgO, aq. H2SO4 / methanol / 3 h / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 9 p. 2620 - 2622
反应条件
1: 100 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 2: 75 percent / K2CO3 / acetonitrile / 12 h / Heating 3: 75 percent / HgO, aq. H2SO4 / methanol / 3 h / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 9 p. 2620 - 2622
