4-(4-羟基联苯甲基)哌啶-1-氧代丁基-2,2-二甲基苯乙酸甲酯合成路线 （共 20 条）
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 30 - 40 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/7347 A1, ;
Page/Page column 4-5; 7; 11 ;
反应条件
1: 75 percent / K2CO3 / acetonitrile / 12 h / Heating 2: 75 percent / HgO, aq. H2SO4 / methanol / 3 h / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 9 p. 2620 - 2622
反应条件
1: acetic acid; hydrogen bromide / toluene / 10 h / 25 °C 2: potassium iodide; sodium hydrogencarbonate / toluene; water / 20 h / |Reflux View Scheme
反应条件
1: sulfuric acid / methanol / 10 h / |Reflux 2: potassium iodide; sodium hydrogencarbonate / toluene; water / 20 h / |Reflux 3: sulfuric acid; water / methanol / 12 h / 40 °C View Scheme
反应条件
1: potassium iodide; sodium hydrogencarbonate / toluene; water / 20 h / |Reflux 2: sulfuric acid; water / methanol / 12 h / 40 °C View Scheme
反应条件
1: sulfuric acid / methanol / 3 h / |Reflux 2: potassium iodide; sodium hydrogencarbonate / toluene; water / 15 h / |Reflux 3: sulfuric acid; water / methanol / 12 h / 40 °C View Scheme
反应条件
1: potassium iodide; sodium hydrogencarbonate / toluene; water / 15 h / |Reflux 2: sulfuric acid; water / methanol / 12 h / 40 °C View Scheme
反应条件
1: 95 percent / NaBH4 / methanol / 20 h / Ambient temperature 2: 76 percent / aq. KOH / methanol / 16 h / 80 °C View Scheme
参考文献
Motta, Giuseppe; Vergani, Domenico
Patent: US2010/16599 A1, 2010 ;
Location in patent: Page/Page column 2 ;
反应条件
1: With sodium hydroxide in water; isopropyl alcohol 5 h; Heating / reflux; 2: With acetic acid in water; isopropyl alcohol pH=5.5 - 6;
参考文献
ARCHIMICA SRL
Patent: WO2008/12858 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
sodium tetrahydroborate in methanol 20 h; Ambient temperature;
参考文献
Kawai, Stephen H.; Hambalek, Robert J.; Just, George
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2620 - 2622
