(2R)-2-(羟基甲基)哌啶-1-羧酸苄酯合成路线 （共 9 条）
参考文献
Coppola, Gary M.; Damon, Robert E.; Eskesen, J. Bruce; France, Dennis S.; Paterniti Jr., James R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 809 - 812
反应条件
1: With acylase I from Aspergillus species in toluene T=20°C; 6 h; Enzymatic reaction; 2: With phosphate buffer; acylase I from Aspergillus species in water T=20°C; pH=7.0; 7 h; Enzymatic reaction;
参考文献
Salgado, Antonio; Mann, Enrique; Sanchez-Sancho, Francisco; Herradon, Bernardo
Heterocycles, 2003 , vol. 60, # 1 p. 57 - 71
反应条件
sodium tetrahydroborate T=20°C;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 31 p. 6309 - 6321
反应条件
acylase I from Aspergillus species in toluene T=20°C; 6 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 60, # 1 p. 57 - 71
反应条件
1: 4N NaOH / 6 h / Ambient temperature 2: BH3.SMe2 / tetrahydrofuran / 10 h / 0 deg C to room temp. View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 47 p. 8871 - 8872
反应条件
1: 4N NaOH / 6 h / Ambient temperature 2: BH3.SMe2 / tetrahydrofuran / 10 h / 0 deg C to room temp. View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 47 p. 8871 - 8872
反应条件
1: pyridine.SO3 / dimethylsulfoxide / 0.5 h / 0 deg C to room temp. 2: benzene / 10 h / Ambient temperature View Scheme
参考文献
Gurjar; Ghosh, Lakshmi; Syamala; Jayasree
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8871 - 8872
反应条件
1: pyridine.SO3 / dimethylsulfoxide / 0.5 h / 0 deg C to room temp. 2: benzene / 10 h / Ambient temperature 3: 1.) AD-mix-β / 1.) t-BuOH, water, 0 deg C - room temp.,24 h 4: water 5: H2, NaOAc / Pd/C / methanol / 12 h / 760 Torr View Scheme
参考文献
Gurjar; Ghosh, Lakshmi; Syamala; Jayasree
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8871 - 8872
反应条件
sulfur trioxide pyridine complex in dimethyl sulfoxide 0.5 h; 0 deg C to room temp.;
参考文献
Gomez, Livia; Garrabou, Xavier; Joglar, Jesus; Bujons, Jordi; Parella, Teodor; Vilaplana, Cristina; Cardona, Pere Joan; Clapes, Pere
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6309 - 6321
