2-氧代-1,2-二氢喹啉-8-基 乙酸酯合成路线 （共 14 条）
反应条件
potassium carbonate in methanol T=20°C; 1 h;
参考文献
Sigouin, Olivier; Beauchamp, Andre L.
Canadian Journal of Chemistry, 2005 , vol. 83, # 5 p. 460 - 470
反应条件
1.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 1.2: 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C 3.1: pyridinium tribromide / tetrahydrofuran / 0 °C / Reflux View Scheme
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
反应条件
1: 93 percent / K2CO3 / methanol / 1 h / 20 °C 2: 41 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Gershon, Herman; Clarke, Donald D.
Monatshefte fuer Chemie, 1991 , vol. 122, # 11 p. 935 - 942
反应条件
1: HCl 2: KOH / H2O 3: K2CO3; KI / methanol 4: H(1+) 5: LiAlBH4 / tetrahydrofuran 6: pyridine 7: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Deyrup; Nowicki; Richards; Otero; Harrison; Baker
Naunyn-Schmiedeberg's Archives of Pharmacology, 1999 , vol. 359, # 3 p. 168 - 177
