1,3-二氧代lo[4,5-g]喹啉-8(5h)-酮合成路线 （共 8 条）
反应条件
hydrogenchloride; sodium methylate in ethylene glycol dimethyl ether; water
参考文献
Kirin Beer Kabushiki Kaisha
Patent: US6187926 B1, 2001 ;
反应条件
diphenylether 1.5 h; Reflux;
参考文献
GENZYME CORPORATION; TEICHER, Beverly, A.; SCHMID, Steven, M.
Patent: WO2012/15901 A1, 2012 ;
Location in patent: Page/Page column 49 ;
反应条件
1: 78 percent / dimethylformamide / 1 h / 100 °C 2: 91 percent / cyclohexane / Pd/C / ethanol / 0.25 h / Heating View Scheme
参考文献
Tois, Jan; Vahermo, Mikko; Koskinen, Ari
Tetrahedron Letters, 2005 , vol. 46, # 5 p. 735 - 737
反应条件
in diphenylether T=200°C; 0.0333333 h; Microwave irradiationIonic liquid;
参考文献
Darque, Albert; Dumetre, Aurelien; Hutter, Sebastien; Casano, Gilles; Robin, Maxime; Pannecouque, Christophe; Azas, Nadine
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5962 - 5964
反应条件
diphenylether T=250°C; 1.5 h;
参考文献
Li, Mingzong; Li, Liangxi; Ge, Haibo
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2445 - 2449
反应条件
1: potassium hydroxide / ethanol / 20 h / Reflux 2: diphenylether / 1.5 h / Reflux View Scheme
参考文献
GENZYME CORPORATION; TEICHER, Beverly, A.; SCHMID, Steven, M.
Patent: WO2012/15901 A1, 2012 ;
反应条件
1.1: 91 percent / POCl3 / 2 h / Heating
2.1: phenol / 2.5 h / Heating
2.2: 65 percent / phenol / 20 h / Heating
3.1: 1.44 g / Et3N / CH2Cl2 / 16 h / Heating
4.1: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag2CO3 / dimethylformamide / 0.5 h / Heating
5.1: 95 percent / formic acid; AcOH / Pd black / 1.5 h / 20 °C
View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
trichlorophosphate
2 h; Heating;
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
