alpha-[2-(二甲基氨基)-1,1-二甲基乙基]苯甲醇合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in methanol 8 h; Heating;
参考文献
Avramova; Dryanovska; Ilarionov
Pharmazie, 1981 , vol. 36, # 6 p. 410 - 412
反应条件
ammonium hydroxide; sodium tetrahydroborate in ethanol 1) 20 deg C, 30 min, 2) reflux, 2h;
参考文献
Tietze, Lutz-F.; Kinast, Guenther
Liebigs Annalen der Chemie, 1980 , # 3 p. 451 - 460
反应条件
1: in isopropyl alcohol 46 h; Inert atmosphereReflux; 2: With sodium tetrahydroborate in methanol T=0°C; 0.75 h; Inert atmosphere;
参考文献
Sasano, Yusuke; Nagasawa, Shota; Yamazaki, Mai; Shibuya, Masatoshi; Park, Jaiwook; Iwabuchi, Yoshiharu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3236 - 3240
Angew. Chem., 2014 , vol. 126, # 12 p. 3300 - 3304,5
参考文献
Anderson,A.G.; Wills,M.T.
Journal of Organic Chemistry, 1968 , vol. 33, # 2 p. 536 - 541
反应条件
2: NaBH4 View Scheme
参考文献
Daruwala,A.B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, # 8 p. 819 - 824
反应条件
4-(N,N-dimethlyamino)pyridine; [2,2']bipyridinyl; AZADO; copper(l) chloride in acetonitrile T=20°C; 2.5 h; chemoselective reaction;
参考文献
Sasano, Yusuke; Nagasawa, Shota; Yamazaki, Mai; Shibuya, Masatoshi; Park, Jaiwook; Iwabuchi, Yoshiharu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3236 - 3240
Angew. Chem., 2014 , vol. 126, # 12 p. 3300 - 3304,5
