4-氧代-哌啶-1,3-二羧酸苄基乙酯合成路线 （共 3 条）
反应条件
1: ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride With hydrogen; palladium dihydroxide in methanol P=2068.65 Torr; 2: benzyl chloroformate With triethylamine in dichloromethane T=0 - 25°C; 15 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/49033 A1, 2005 ;
Location in patent: Page/Page column 123 ;
WO 2005/049033 A1
反应条件
1: 4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester With trifluoroacetic acid in dichloromethane T=5 - 10°C; 2: benzyl chloroformate With triethylamine in dichloromethane T=0 - 20°C;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 95-96 ;
WO 2010/016005 A1
反应条件
N-ethyl-N,N-diisopropylamine
参考文献
US6664271 B1, ;
Page column 10 ;
