4-溴-3-羟基-6-吡嗪酮合成路线 （共 10 条）
反应条件
hydrazine hydrate in tetrahydrofuran
参考文献
Merck Sharp and Dohme Ltd.
Patent: US6303605 B1, 2001 ;
US 6303605 B1
参考文献
EP1980251 A1, ;
EP 1980251 A1
反应条件
trichlorophosphate 4 h; Heating;
参考文献
Kasnar; Wise; Kucera; Drach; Townsend
Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 459 - 479
反应条件
1: With trichlorophosphate 3.5 h; Heating / reflux; 2: With sodium hydrogencarbonate in water
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/6648 A1, 2008 ;
Location in patent: Page/Page column 52-53 ;
反应条件
trichlorophosphate 3.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/115947 A1, 2007 ;
Location in patent: Page/Page column 30 ;
反应条件
trichlorophosphate 3.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/9700 A1, 2008 ;
Location in patent: Page/Page column 38-39 ;
WO 2008/009700 A1
反应条件
in dichloromethane; trichlorophosphate
参考文献
Merck Sharp and Dohme Limited
Patent: US6255305 B1, 2001 ;
US 6255305 B1
反应条件
trichlorophosphate 3.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/115947 A1, 2007 ;
Location in patent: Page/Page column 30 ;
反应条件
trichlorophosphate 3.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/9700 A1, 2008 ;
Location in patent: Page/Page column 38-39 ;
WO 2008/009700 A1
反应条件
sodium carbonate; tetrakis (triphenylphosphine) palladium (0) in ethylene glycol dimethyl ether; trichlorophosphate
参考文献
Merck Sharp and Dohme Limited
Patent: US6255305 B1, 2001 ;
US 6255305 B1
