1-(2-氟-4-硝基苯基)哌嗪合成路线 （共 6 条）
反应条件
in acetonitrile T=80°C; 2 h;
参考文献
Schaus, Scott E.; Jacobsen, Eric N.
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940
反应条件
1: With hydrogenchloride in ethyl acetate T=0 - 20°C; 12 h; 2: With sodium hydrogencarbonate in water; ethyl acetate pH=9;
参考文献
INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC.
Patent: US2008/227784 A1, 2008 ;
Location in patent: Page/Page column 39 ;
反应条件
1: TEA / CH2Cl2 / 0 - 20 °C 2: H2 / Pd/C / methanol / 20 °C / 2844.31 Torr View Scheme
参考文献
Das, Biswajit; Rudra, Sonali; Yadav, Ajay; Ray, Abhijit; Raja Rao; Srinivas; Soni, Ajay; Saini, Suman; Shukla, Shalini; Pandya, Manisha; Bhateja, Pragya; Malhotra, Sunita; Mathur, Tarun; Arora; Rattan, Ashok; Mehta, Anita
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4261 - 4267
反应条件
sodium hydroxide in 1,4-dioxane; water T=25 - 35°C; 0.5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.
Patent: WO2005/82892 A2, 2005 ;
Location in patent: Page/Page column 61 ;
参考文献
Orchid Chemicals & Pharmaceuticals Ltd
Patent: WO2004/18439 A1, 2004 ;
Location in patent: Page 30; 31 ;
反应条件
1.1: TEA / CH2Cl2 / 0 - 20 °C 2.1: H2 / Pd/C / methanol / 20 °C / 2844.31 Torr 3.1: NaHCO3 / tetrahydrofuran 4.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C 4.2: tetrahydrofuran View Scheme
参考文献
Das, Biswajit; Rudra, Sonali; Yadav, Ajay; Ray, Abhijit; Raja Rao; Srinivas; Soni, Ajay; Saini, Suman; Shukla, Shalini; Pandya, Manisha; Bhateja, Pragya; Malhotra, Sunita; Mathur, Tarun; Arora; Rattan, Ashok; Mehta, Anita
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4261 - 4267
