4-(4-Boc-哌嗪-1-基)-3-氟苯胺合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=3000.3 Torr; 6 h;
参考文献
Dong Wha Pharm. Co., Ltd.
Patent: EP2394993 A2, 2011 ;
Location in patent: Page/Page column 23 ;
反应条件
1: N-ethyldiisopropylamine / acetonitrile / 80 °C 2: TEA / CH2Cl2 / 0 - 20 °C 3: H2 / Pd/C / methanol / 20 °C / 2844.31 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 19 p. 4261 - 4267
反应条件
1: triethylamine / methanol / 17 h / 50 - 60 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 6 h / 3000.3 Torr View Scheme
参考文献
EP2394993 A2, ;
US2011/306606 A1, ;
US 20110306606 A1
反应条件
1: TEA / CH2Cl2 / 0 - 20 °C 2: H2 / Pd/C / methanol / 20 °C / 2844.31 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 19 p. 4261 - 4267
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 5 °C 2: hydrogen / Raney Ni / dichloromethane; methanol / 1 h / 2585.81 Torr View Scheme
反应条件
1.1: NaHCO3 / tetrahydrofuran 2.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C 2.2: tetrahydrofuran View Scheme
参考文献
Roehrig, Susanne; Straub, Alexander; Pohlmann, Jens; Lampe, Thomas; Pernerstorfer, Josef; Schlemmer, Karl-Heinz; Reinemer, Peter; Perzborn, Elisabeth
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5900 - 5908
