1-(2-氨基-5-氯苯基)-2,2,2-三氟乙酮合成路线 （共 30 条）
反应条件
hydrogenchloride; acetic acid in water T=65 - 70°C; 4 h;
参考文献
BIOLIPOX AB
Patent: WO2006/77367 A1, 2006 ;
Location in patent: Page/Page column 115 ;
WO 2006/077367 A1
反应条件
sodium carbonate in dimethoxyethane (DME) pH=9;
参考文献
WO2006/98969 A2, ;
Page/Page column 35-37 ;
WO 2006/098969 A2
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran; dimethyl sulfoxide T=20°C; 18 h; 2: With hydrogenchloride; water in tetrahydrofuran; dimethyl sulfoxide 1 h;
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran; dimethyl sulfoxide T=20°C; 15 h; 2: With hydrogenchloride; water in tetrahydrofuran; dimethyl sulfoxide 1 h;
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 388 - 391
反应条件
hydrogenchloride; n-butyllithium 1.) THF, 2.) ethyl acetate, 60 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 36, # 49 p. 8937 - 8940
反应条件
1: n-BuLi / tetrahydrofuran 2: 3N aq. HCl View Scheme
参考文献
Antimicrobial Agents and Chemotherapy, , vol. 39, # 12 p. 2602 - 2605
反应条件
1: Et3N 2: n-BuLi / tetrahydrofuran 3: 3N aq. HCl View Scheme
参考文献
Antimicrobial Agents and Chemotherapy, , vol. 39, # 12 p. 2602 - 2605
反应条件
1: aq. NaIO4; OsO4 / 2-methyl-propan-2-ol 2: hydrogen; Raney Ni / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 24 p. 4083 - 4085
反应条件
1.1: triethylamine / toluene / 15 h / 110 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dimethyl sulfoxide / 18 h / 20 °C 2.2: 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 388 - 391
反应条件
1: triethylamine / toluene / 15 h / 110 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 388 - 391
