5-氟苯并[b]噻吩-2-羧酸甲酯合成路线 （共 4 条）
反应条件
palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran T=110°C; P=7757.43 Torr; 15 h; Autoclave;
参考文献
Zeng, Fanlong; Alper, Howard
Organic Letters, 2011 , vol. 13, # 11 p. 2868 - 2871
反应条件
triethylamine in acetonitrile RefluxInert atmosphere;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0827 ;
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran / -70 - -10 °C 2: manganese(IV) oxide / dichloromethane / 2 h / 52 °C View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=-70 - -10°C; 2 h; 2: With methanol in tetrahydrofuran T=-70°C;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0829 ;
