(S)-2-(2-溴苯基)-4-叔丁基-4,5-二氢噁唑合成路线 （共 10 条）
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane T=4 - 50°C; 5 h; Inert atmosphere;
参考文献
Kraut, Michael R.; Mohr, Justin T.; Stoltz, Brian M.; Schumacher, Andreas; Pfaltz, Andreas
Organic Syntheses, 2009 , vol. 86, p. 181 - 193
反应条件
1: 89.5 percent / Na2CO3 / CH2Cl2; H2O / 12 h / 20 °C 2: 81.2 percent / p-toluenesulfonyl chloride; triethylamine / CH2Cl2 / 22 h / 55 °C View Scheme
参考文献
Campbell Bourland; Carter, Rich G.; Yokochi, Alexandre F. T.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1315 - 1329
反应条件
1: 89.5 percent / Na2CO3 / CH2Cl2; H2O / 12 h / 20 °C 2: 81.2 percent / p-toluenesulfonyl chloride; triethylamine / CH2Cl2 / 22 h / 55 °C View Scheme
参考文献
Campbell Bourland; Carter, Rich G.; Yokochi, Alexandre F. T.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1315 - 1329
反应条件
zinc(II) chloride in chlorobenzene 24 h; Heating;
参考文献
Zhou, Qi-Lin; Pfaltz, Andreas
Tetrahedron, 1994 , vol. 50, # 15 p. 4467 - 4478
反应条件
1: With sodium hydrogencarbonate Inert atmosphere; 2: With triethylamine; p-toluenesulfonyl chloride Inert atmosphere;
参考文献
Garcia-Fortanet, Jorge; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 42 p. 8108 - 8111
反应条件
1: sodium tetrahydroborate; iodine / tetrahydrofuran / 18.5 h / 4 - 80 °C / Inert atmosphere 2: sodium carbonate / dichloromethane; water / 10.25 h / 20 °C 3: methanesulfonyl chloride; triethylamine / dichloromethane / 5 h / 4 - 50 °C / Inert atmosphere View Scheme
参考文献
Kraut, Michael R.; Mohr, Justin T.; Stoltz, Brian M.; Schumacher, Andreas; Pfaltz, Andreas
Organic Syntheses, 2009 , vol. 86, p. 181 - 193
反应条件
1: dichloromethane / Molecular sieve; Inert atmosphere 2: N-bromosuccinmide / dichloromethane / Inert atmosphere View Scheme
参考文献
Weise, Christian F.; Pischl, Matthias C.; Pfaltz, Andreas; Schneider, Christoph
Journal of Organic Chemistry, 2012 , vol. 77, # 3 p. 1477 - 1488
反应条件
1: thionyl chloride / 4 h / 80 °C 2: triethylamine / 0 - 20 °C 3: triethylamine / 0 - 20 °C 4: sodium hydroxide / methanol; water / 4 h / Reflux View Scheme
参考文献
Jin, Yu; Du, Da-Ming
Tetrahedron, 2012 , vol. 68, # 18 p. 3633 - 3640
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride T=20°C; 6 h; Inert atmosphere; 2: With triethylamine; p-toluenesulfonyl chloride T=20°C; 12 h; Inert atmosphere;
参考文献
Hu, Zongjian; Li, Yuguang; Liu, Kai; Shen, Qilong
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7957 - 7967
反应条件
1: bis-diphenylphosphine With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in toluene T=20°C; 0.333333 h; Inert atmosphere; 2: 2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole With caesium carbonate in toluene T=110°C; 21 h; Inert atmosphereSealed vessel;
参考文献
Kraut, Michael R.; Mohr, Justin T.; Stoltz, Brian M.; Schumacher, Andreas; Pfaltz, Andreas
Organic Syntheses, 2009 , vol. 86, p. 181 - 193
