1-N-BOC-4-哌啶丙酸合成路线 （共 23 条）
反应条件
1: 98 percent / aq. K2CO3 / tetrahydrofuran / 4 h / Ambient temperature 2: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 3: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 4: 81.5 percent / CHCl3 / 16 h / Heating 5: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 6: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 2: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 3: 81.5 percent / CHCl3 / 16 h / Heating 4: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 5: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 2: 81.5 percent / CHCl3 / 16 h / Heating 3: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 4: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 81.5 percent / CHCl3 / 16 h / Heating 2: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 3: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 2: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 15 - 20 °C 1.2: 78 percent / tetrahydrofuran / 20 °C 2.1: 88 percent / HCl; H2 / PtO2 / ethanol; dioxane / 5 h / 45 °C 3.1: 81 percent / triethylamine / CH2Cl2 / 5 h / 20 °C 4.1: 91 percent / aq. NaOH / tetrahydrofuran; ethanol / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 13 p. 4343 - 4352
反应条件
1: 88 percent / HCl; H2 / PtO2 / ethanol; dioxane / 5 h / 45 °C 2: 81 percent / triethylamine / CH2Cl2 / 5 h / 20 °C 3: 91 percent / aq. NaOH / tetrahydrofuran; ethanol / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 13 p. 4343 - 4352
反应条件
1.1: H2; aq. AcOH / PtO2 2.1: NaOH 2.2: KHSO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 13 p. 1629 - 1633
反应条件
1: 97 percent / triethylamine / dioxane; H2O / 96 h / 20 °C 2: 91 percent / aq. sodium hydroxide / ethanol / 12 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 7 p. 1329 - 1345
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating / reflux; 2: With water in tetrahydrofuran T=0 - 20°C; 0.25 h; 3: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 18.25 h;
参考文献
Buzard, Daniel J.; Edwards, James P.; Kindrachuk, David E.; Venable, Jennifer D.
Patent: US2005/261309 A1, 2005 ;
Location in patent: Page/Page column 17 ;
