4,5-二甲氧基-1H-吲哚-3-甲醛合成路线 （共 7 条）
反应条件
trichlorophosphate T=0 - 40°C; Vilsmeier formylation;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=110 - 120°C; 0.75 h;
参考文献
Moody, Christopher J.; Swann, Elizabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2561 - 2566
反应条件
1: 57 percent / methanol / -10 °C 2: 63 percent / xylene / Heating 3: 93 percent / aq. NaOH / Heating 4: 83 percent / Cu; quinoline / Heating 5: 57 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 83 percent / Cu; quinoline / Heating 2: 57 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 93 percent / aq. NaOH / Heating 2: 83 percent / Cu; quinoline / Heating 3: 57 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 93 percent / phosphorus oxychloride / 1 h / 35 °C 2: 1.) thallium(III) trifluoroacetate, 2.) aq. potassium iodide / 1) CF3CO2H, 2 h, 30 deg C; 2) 15 min 3: 22 percent / copper iodide / dimethylformamide / 0.75 h / 110 - 120 °C View Scheme
参考文献
Moody, Christopher J.; Swann, Elizabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2561 - 2566
反应条件
1: 1.) thallium(III) trifluoroacetate, 2.) aq. potassium iodide / 1) CF3CO2H, 2 h, 30 deg C; 2) 15 min 2: 22 percent / copper iodide / dimethylformamide / 0.75 h / 110 - 120 °C View Scheme
参考文献
Moody, Christopher J.; Swann, Elizabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2561 - 2566
