2-(4-溴苯基)-2,2-二甲基乙酸甲酯合成路线 （共 17 条）
反应条件
1: 97 percent / Et3N / tetrakis(triphenylphosphine)palladium(0), Cu2Br2 / 3.5 h / Heating 2: 100 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 3: 75 percent / K2CO3 / acetonitrile / 12 h / Heating View Scheme
参考文献
Kawai, Stephen H.; Hambalek, Robert J.; Just, George
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2620 - 2622
反应条件
copper(l) iodide; triphenylphosphine; palladium dichloride in N,N-dimethyl-formamide 10 h; Heating / reflux;
参考文献
Dinamite Dipharma S.p.A.
Patent: EP1260505 A1, 2002 ;
Location in patent: Example 6 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 3.75 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John
Patent: WO2010/86820 A1, 2010 ;
Location in patent: Page/Page column 50 ;
WO 2010/086820 A1
反应条件
1: 97 percent / Et3N / tetrakis(triphenylphosphine)palladium(0), Cu2Br2 / 3.5 h / Heating 2: 100 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 3: 75 percent / K2CO3 / acetonitrile / 12 h / Heating 4: 75 percent / HgO, aq. H2SO4 / methanol / 3 h / 55 °C View Scheme
参考文献
Kawai, Stephen H.; Hambalek, Robert J.; Just, George
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2620 - 2622
反应条件
triethylamine; copper(I) bromide; tetrakis(triphenylphosphine) palladium(0) 3.5 h; Heating;
参考文献
Kawai, Stephen H.; Hambalek, Robert J.; Just, George
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2620 - 2622
反应条件
1: α,α-dimethyl-(4-bromophenyl)acetic acid methyl ester; ethynylmethyl carbinol With potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in toluene 24 h; Reflux; 2: With sulfuric acid; mercury(II) oxide in methanol; water T=25 - 35°C; 2 h; 3: 4-(hydroxy-diphenyl-methyl)-piperidine
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 97 percent / Et3N / tetrakis(triphenylphosphine)palladium(0), Cu2Br2 / 3.5 h / Heating 2: 100 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 3: 75 percent / K2CO3 / acetonitrile / 12 h / Heating 4: 75 percent / HgO, aq. H2SO4 / methanol / 3 h / 55 °C 5: 95 percent / NaBH4 / methanol / 20 h / Ambient temperature View Scheme
参考文献
Kawai, Stephen H.; Hambalek, Robert J.; Just, George
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2620 - 2622
