2-(羟甲基)丙烯酸甲酯合成路线 （共 28 条）
反应条件
sulfuric acid a.) 0 deg C, 5 min, b.) 20 deg C, 35 min;
参考文献
Vloon, Wilhelmus J.; Bos, Jan C. van den; Koomen, Gerrit-Jan; Pandit, Upendra K.
Tetrahedron, 1992 , vol. 48, # 38 p. 8317 - 8328
反应条件
pyridine in diethyl ether T=20°C; 0.5 h; Inert atmosphere;
参考文献
Wassenaar, Jeroen; Kuil, Mark; Reek, Joost N. H.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1610 - 1614
反应条件
methanol; potassium hydroxide in tetrahydrofuran; water
T=20°C; 24 h;
参考文献
Mendgen, Thomas; Scholz, Therese; Klein, Christian D.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5757 - 5762
反应条件
1: anhydrous xylene / Heating
2: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 20 °C
View Scheme
参考文献
Bizet, Vincent; Lefebvre, Valerie; Baudoux, Jerome; Lasne, Marie-Claire; Boulange, Agathe; Leleu, Stephane; Franck, Xavier; Rouden, Jacques
European Journal of Organic Chemistry, 2011 , # 22 p. 4170 - 4175
反应条件
1: anhydrous xylene / Heating
2: phenylmethyltriethylammonium bromide; caesium carbonate / water / 17 h / 20 °C
View Scheme
参考文献
Bizet, Vincent; Lefebvre, Valerie; Baudoux, Jerome; Lasne, Marie-Claire; Boulange, Agathe; Leleu, Stephane; Franck, Xavier; Rouden, Jacques
European Journal of Organic Chemistry, 2011 , # 22 p. 4170 - 4175
反应条件
1: anhydrous xylene / Heating
2: tetramethylpiperidine / dichloromethane / 312 h / 20 °C
View Scheme
参考文献
Bizet, Vincent; Lefebvre, Valerie; Baudoux, Jerome; Lasne, Marie-Claire; Boulange, Agathe; Leleu, Stephane; Franck, Xavier; Rouden, Jacques
European Journal of Organic Chemistry, 2011 , # 22 p. 4170 - 4175
反应条件
1: anhydrous xylene / Heating
2: triethylamine / dichloromethane / 17 h / 20 °C
View Scheme
参考文献
Bizet, Vincent; Lefebvre, Valerie; Baudoux, Jerome; Lasne, Marie-Claire; Boulange, Agathe; Leleu, Stephane; Franck, Xavier; Rouden, Jacques
European Journal of Organic Chemistry, 2011 , # 22 p. 4170 - 4175
反应条件
1: methyl 3-hydroxy-2-methylidene-propanoate With magnesium iodide in dichloromethane
Cooling with acetone-dry iceInert atmosphere;
2: 2-iodo-propane With triethyl borane; tri-n-butyl-tin hydride in hexane; dichloromethane
T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Korea Institute of Science and Technology; MIN, Sun Joon; Cho, Yong Seo; Lee, Jae Kyun; Pae, Ae Nim; Son, Young Wook
Patent: US2013/197227 A1, 2013 ;
Location in patent: Paragraph 0035; 0036; 0037 ;
