2,4,6-三羟基苯基-4'-羟基苄基甲酮合成路线 （共 16 条）
反应条件
boron trifluoride diethyl etherate T=0°C; 5 h;
参考文献
Waehaelae, Kristiina; Hase, Tapio A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3005 - 3008
反应条件
1: With hydrogenchloride in methyl acetate T=5 - 20°C; Hoesch reaction; 19 h; 2: With sodium hydroxide; ethanol; water in ethyl acetate T=75 - 101°C; pH=4.0; 7 h; Heating / reflux; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2006/111289 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium hydroxide T=60°C;
参考文献
Li, Huan-Qiu; Xue, Jia-Yu; Shi, Lei; Gui, Shan-Ying; Zhu, Hai-Liang
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 662 - 667
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Bulletin de la Societe Chimique de France, , p. 2309 - 2322
反应条件
hydrogenchloride; water Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 21 p. 6835 - 6850
反应条件
1: sodium formate; propionyl chloride in acetone T=21 - 35°C; 3 h; 2: 2,4,6-trihydroxy-α-p-hydroxyphenylacetophenone With triethylamine in acetone T=20 - 22°C; 2 h; 3: With sulfuric acid; water in acetone T=20°C; 16 h;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 17 ;
反应条件
1: formic acid; propionic acid anhydride T=25 - 45°C; 2 h; 2: 2,4,6-trihydroxy-α-p-hydroxyphenylacetophenone With triethylamine in acetone T=20 - 40°C; 19 h; 3: With sulfuric acid; water in acetone T=60°C;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 20 ;
反应条件
1: in acetone T=21 - 32°C; 3 h; 2: With triethylamine in acetone T=18 - 32°C; 2 h; 3: With sulfuric acid; water in acetone T=60 - 70°C; 3 h;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 23 ;
反应条件
1: With triethylamine in acetone T=25 - 40°C; 3 h; 2: With sulfuric acid; water in acetone T=20 - 60°C;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 15; 16 ;
反应条件
1: sodium formate; benzoyl chloride in acetone T=21 - 40°C; 3 h; 2: 2,4,6-trihydroxy-α-p-hydroxyphenylacetophenone With triethylamine in acetone T=21 - 35°C; 3 h; 3: With sulfuric acid; water in acetone T=20°C; 16 h;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 21; 22 ;
