2,4,6-三羟基苯基-4'-羟基苄基甲酮合成路线 （共 16 条）
反应条件
1: N,N-dimethyl-formamide With phosphorus pentachloride T=55°C; Chlorination; 0.333333 h; 2: 2,4,6-trihydroxy-α-p-hydroxyphenylacetophenone With boron trifluoride diethyl etherate in N,N-dimethyl-formamide T=20°C; Cycloaddition; 1 h;
参考文献
Balasubramanian, Sreenivasan; Nair, Muraleedharan G.
Synthetic Communications, 2000 , vol. 30, # 3 p. 469 - 484
反应条件
1: With propionyl chloride in acetone T=21 - 32°C; 1 h; 2: With triethylamine in acetone T=20 - 32°C; 2.5 h; 3: With sulfuric acid; water in acetone T=20°C; 16 h; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2006/111289 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
boron trifluoride diethyl etherate; methanesulfonyl chloride in N,N-dimethyl-formamide T=50°C; 12 h; Molecular sieve;
参考文献
Wu, Zhongtao; Lian, Gaoyana; Yu, Biao; Wang, Zhenzhongc; Zhao, Yiwuc; Xiao, Wei
Chinese Journal of Chemistry, 2010 , vol. 28, # 9 p. 1725 - 1730
反应条件
1: in acetone T=0 - 5°C; 3 h; 2: With triethylamine in acetone T=0 - 20°C; 17 h; 3: With sulfuric acid; water in acetone T=70°C; 3 h;
参考文献
ROCHE VITAMINS AG
Patent: WO2004/9576 A2, 2004 ;
Location in patent: Page 22 ;
反应条件
sulfuric acid in N,N-dimethyl-formamide 1 h;
参考文献
Harms, Arthur E.
Patent: US2009/62555 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
boron trifluoride diethyl etherate; acetic anhydride in diethyl ether; acetic acid Heating;
参考文献
Jah, Hem Chandra; Zilliken, Fritz; Breitmaier, Eberhard
Angewandte Chemie, 1981 , vol. 93, # 1 p. 129 - 130
