2-羟基-4-三氟甲基嘧啶-5-羧酸乙酯合成路线 （共 9 条）
反应条件
1: in ethanol T=80°C; 4 h; 2: With sodium ethanolate in ethanol T=20°C; 2.25 h; 3: With acetic acid in ethanol T=20 - 30°C;
参考文献
LONZA AG
Patent: WO2006/48297 A1, 2006 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
sodium ethanolate in ethanol Condensation; cyclization; Heating;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
sodium ethanolate in ethanol T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1: Heating 2: NaOEt / ethanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1: POCl3 / 1 h / Heating 2: 1 N aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: POCl3 / 3 h / Heating 2: hydrazine / tetrahydrofuran / 0.08 h / 20 °C View Scheme
参考文献
Palanki, Moorthy S.S.; Gayo-Fung, Leah M.; Shevlin, Graziella I.; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J.; Spooner, Cheryl
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2573 - 2577
反应条件
1: POCl3 / 1 h / Heating 2: 1 N aq. NaOH / tetrahydrofuran 3: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: POCl3 / 3 h / Heating 2: NH3 / tetrahydrofuran / 6 h / 0 - 20 °C View Scheme
参考文献
Palanki, Moorthy S.S.; Gayo-Fung, Leah M.; Shevlin, Graziella I.; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J.; Spooner, Cheryl
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2573 - 2577
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
