2-氯-4-(三氟甲基)吡啶-5-羰酰氯合成路线 (共 5 条)
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Chlorination;
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 45 percent / NaOEt / ethanol / Heating 2: POCl3 / 1 h / Heating 3: 1 N aq. NaOH / tetrahydrofuran 4: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 1 N aq. NaOH / tetrahydrofuran 2: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: POCl3 / 1 h / Heating 2: 1 N aq. NaOH / tetrahydrofuran 3: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5811428 A1, 1998 ;