1-氯-2-硝基-4-三氟甲烷磺酰基苯合成路线 （共 9 条）
反应条件
sulfuric acid; potassium nitrate T=100 - 110°C; 4 h;
参考文献
Bernasconi, Claude F.; Howard, Keith A.
Journal of the American Chemical Society, 1982 , vol. 104, # 25 p. 7248 - 7257
反应条件
1: 85.4 percent / CrO3 / acetic acid / 3 h / 100 - 105 °C 2: 70 percent / KNO3, H2SO4 / 4 h / 100 - 110 °C View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 60 - 65
反应条件
1: 7.0 g / SbF3 / Heating 2: 85.4 percent / CrO3 / acetic acid / 3 h / 100 - 105 °C 3: 70 percent / KNO3, H2SO4 / 4 h / 100 - 110 °C View Scheme
参考文献
Bernasconi, Claude F.; Howard, Keith A.
Journal of the American Chemical Society, 1982 , vol. 104, # 25 p. 7248 - 7257
反应条件
1: 83 percent / Cl2 / CHCl3 / Heating 2: 7.0 g / SbF3 / Heating 3: 85.4 percent / CrO3 / acetic acid / 3 h / 100 - 105 °C 4: 70 percent / KNO3, H2SO4 / 4 h / 100 - 110 °C View Scheme
参考文献
Bernasconi, Claude F.; Howard, Keith A.
Journal of the American Chemical Society, 1982 , vol. 104, # 25 p. 7248 - 7257
反应条件
1: With sodium hydroxide in methanol; water T=20 - 110°C; 1 h; 2: With hydrogenchloride in methanol; water
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/37294 A1, 2009 ;
Location in patent: Page/Page column 112-113 ;
WO 2009/037294 A1
反应条件
oxygen in N,N-dimethyl-formamide T=22 - 23°C; 1272 h; other temperatures, order of reaction, energy og activation in the presence of H2O18; Thermodynamic dataKineticsProduct distribution;
参考文献
Ivanova, T.M.; Shein, S.M.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 891 - 897
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 5 p. 891 - 897
反应条件
2: SnCl2; aqueous HCl
3: benzene
View Scheme
参考文献
Jagupol'skii; Troizkaja
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2409,2415; engl. Ausg. S. 2374, 2379
反应条件
oxygen in N,N-dimethyl-formamide
T=22 - 23°C; 1272 h; other temperatures, order of reaction, energy og activation in the presence of H2O18; Thermodynamic dataKineticsProduct distribution;
参考文献
Ivanova, T.M.; Shein, S.M.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 891 - 897
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 5 p. 891 - 897
参考文献
Ochal, Zbigniew; Bretner, Maria; Wolinowska, Renata; Tyski, Stefan
Medicinal Chemistry, 2013 , vol. 9, # 8 p. 1129 - 1136
