2-氧代-3-(噻吩-2-基)丙酸合成路线 （共 6 条）
反应条件
sodium perborate in water 48 h; Ambient temperature;
参考文献
Morrow, Nicholas; Ramsden, Christopher A.; Sargent, Bruce J.; Wallett, Christiaan D.
Tetrahedron, 1998 , vol. 54, # 33 p. 9603 - 9612
反应条件
potassium tert-butylate; citric acid; Cu2O in diethyl ether; n-heptane; ethyl acetate
参考文献
Klaubert, Dieter H.; Meisenheimer, Poncho; Unch, James
Patent: US2012/117667 A1, 2012 ;
反应条件
1: With sodium hydroxide
T=80°C;
2: With hydrogenchloride
5 h; Heating;
参考文献
Yamashita, Ayako; Norton, Emily B.; Kaplan, Joshua A.; Niu, Chuan; Loganzo, Frank; Hernandez, Richard; Beyer, Carl F.; Annable, Tami; Musto, Sylvia; Discafani, Carolyn; Zask, Arie; Ayral-Kaloustian, Semiramis
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5317 - 5322
反应条件
L-amino acid oxidase; catalase
4 h; Ambient temperaturetris-HCl pH 8 buffer;
参考文献
Forbes, Brian J.R.; Hamilton, Gordon A.
Bioorganic Chemistry, 1994 , vol. 22, # 4 p. 343 - 361
反应条件
1.1: NaOAc; Ac2O / 5 h / Heating
2.1: aq. NaOH / 80 °C
2.2: aq. HCl / 5 h / Heating
View Scheme
参考文献
Yamashita, Ayako; Norton, Emily B.; Kaplan, Joshua A.; Niu, Chuan; Loganzo, Frank; Hernandez, Richard; Beyer, Carl F.; Annable, Tami; Musto, Sylvia; Discafani, Carolyn; Zask, Arie; Ayral-Kaloustian, Semiramis
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5317 - 5322
反应条件
1: sodium ethylate; ethanol
2: aqueous hydrochloric acid; acetic acid
View Scheme
参考文献
Cagniant
Annales de Chimie (Cachan, France), 1952 , vol. <12> 7, p. 442,464
