7,8-二氢-1,6-萘啶-5(6H)-酮合成路线 （共 8 条）
反应条件
ammonium chloride; acetic acid in water 4 h; Reflux;
参考文献
Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
反应条件
potassium carbonate; dimethyl sulfate in acetone
反应条件
1: 70 percent / 2,6-di-t-butyl-4-methylphenol / (Ph3P)2Pd(II)Cl2 / dimethylformamide / 68 h / 40 - 55 °C 2: 40 percent / NH4Cl / acetic acid; H2O / 5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 5 p. 1311 - 1317
反应条件
1: 84 percent / K2CO3 / acetone / 25 °C 2: 70 percent / 2,6-di-t-butyl-4-methylphenol / (Ph3P)2Pd(II)Cl2 / dimethylformamide / 68 h / 40 - 55 °C 3: 40 percent / NH4Cl / acetic acid; H2O / 5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 5 p. 1311 - 1317
反应条件
ammonium chloride in water; acetic acid 5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 5 p. 1311 - 1317
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C 2: hydrogen; palladium / ethyl acetate / 4 h / 20 °C 3: ammonium chloride; acetic acid / water / 4 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 58 - 66,9
反应条件
1: hydrogen; palladium / ethyl acetate / 4 h / 20 °C 2: ammonium chloride; acetic acid / water / 4 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 58 - 66,9
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 55 °C 2: ammonium chloride; acetic acid / water / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 11 p. 3407 - 3410
