(7alpha,17beta)-3-甲氧基-7-甲基-雌甾-1,3,5(10)-三烯-17-醇合成路线 （共 10 条）
反应条件
1: With copper(ll) bromide in toluene T=17 - 23°C; Industry scale; 2: With potassium hydroxide in water Heating / refluxIndustry scale;
参考文献
RESOLUTION CHEMICALS LIMITED
Patent: WO2004/78774 A1, 2004 ;
Location in patent: Page 35-36 ;
反应条件
hydrogenchloride in tetrahydrofuran T=22°C; 16 h;
参考文献
Kuenzer, Hermann; Sauer, Gerhard; Wiechert, Rudolf
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 743 - 746
反应条件
triethylsilane; boron trifluoride diethyl etherate in dichloromethane T=0°C; 12 h;
参考文献
Tedesco, Rosanna; Katzenellenbogen, John A.; Napolitano, Elio
Tetrahedron Letters, 1997 , vol. 38, # 46 p. 7997 - 8000
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=23°C; 3 h;
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
1: 78 percent / 1M KOt-Bu / 1,2-dimethoxy-ethane; tetrahydrofuran / 2 h / -78 °C 2: 95 percent / BF3*Et2O, Et3SiH / CH2Cl2 / 12 h / 0 °C View Scheme
参考文献
Tedesco, Rosanna; Katzenellenbogen, John A.; Napolitano, Elio
Tetrahedron Letters, 1997 , vol. 38, # 46 p. 7997 - 8000
反应条件
1: 55 percent / NH3, Li / tetrahydrofuran / 3 h / -50 °C 2: 92 percent / pyridine / CHCl3 / 48 h / 22 °C 3: 71 percent / NaI, Zn, H2O / 1,2-dimethoxy-ethane / 24 h / 90 °C 4: 90 percent / aq. HCl / tetrahydrofuran / 16 h / 22 °C View Scheme
参考文献
Kuenzer, Hermann; Sauer, Gerhard; Wiechert, Rudolf
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 743 - 746
反应条件
1: 92 percent / pyridine / CHCl3 / 48 h / 22 °C 2: 71 percent / NaI, Zn, H2O / 1,2-dimethoxy-ethane / 24 h / 90 °C 3: 90 percent / aq. HCl / tetrahydrofuran / 16 h / 22 °C View Scheme
参考文献
Kuenzer, Hermann; Sauer, Gerhard; Wiechert, Rudolf
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 743 - 746
反应条件
1: 71 percent / NaI, Zn, H2O / 1,2-dimethoxy-ethane / 24 h / 90 °C 2: 90 percent / aq. HCl / tetrahydrofuran / 16 h / 22 °C View Scheme
参考文献
Kuenzer, Hermann; Sauer, Gerhard; Wiechert, Rudolf
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 743 - 746
反应条件
1: Na, tBuOH, liq. NH3 / tetrahydrofuran 2: Al(OiPr)3, cyclohexanone / toluene 3: ethane-1,2-diamine / dimethylsulfoxide; toluene 4: aq. oxalic acid / methanol View Scheme
参考文献
Wieland,P.; Anner,G.
Helvetica Chimica Acta, 1967 , vol. 50, p. 1453 - 1461
