1-甲基-2-氧代-1,2-二氢吡啶-3-羧酸合成路线 （共 17 条）
反应条件
nachfolgend Erhitzen mit Methyljodid im Rohr auf 100grad, und Erwaermen des Reaktionsprodukts mit Alkalilauge;
参考文献
Chemische Berichte, , vol. 56, p. 884
反应条件
1.1: SOCl2 / 1 h / Heating
1.2: 92 percent / 0.5 h / Heating
2.1: 47 percent / diisobutylaluminum hydride / tetrahydrofuran / 3 h / 0 °C
View Scheme
参考文献
Sieburth, Scott McN.; McGee Jr., Kevin F.; Zhang, Fangning; Chen, Yanping
Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 1972 - 1977
反应条件
1: 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid With thionyl chloride
Substitution; 1 h; Heating;
2: methanol Substitution; 0.5 h; Heating; Further stages.;
参考文献
Sieburth, Scott McN.; McGee Jr., Kevin F.; Zhang, Fangning; Chen, Yanping
Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 1972 - 1977
反应条件
1: thionyl chloride / 1.5 h / Heating
2: 0.5 h / Heating
View Scheme
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
反应条件
1: (COCl)2 / benzene / a) RT, 3 h, b) 50 - 55 deg C, 30 min
2: 70 percent / benzene / 0.17 h / Ambient temperature
View Scheme
参考文献
Duong, Thach; Prager, Rolf H.; Were, Stephen T.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1431 - 1440
反应条件
1: (COCl)2 / benzene / a) RT, 3 h, b) 50 - 55 deg C, 30 min
2: AlCl3 / 6 h / Heating
3: 70 percent / NaBH4 / ethanol / 0.5 h
4: 70 percent / sodium azide, 98percent H2SO4 / CHCl3 / a) RT, overnight, b) 50 deg C, 1 h
View Scheme
参考文献
Duong, Thach; Prager, Rolf H.; Were, Stephen T.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1431 - 1440
反应条件
thionyl chloride
1.5 h; Heating;
参考文献
Masu, Hyuma; Ohmori, Ken; Kishikawa, Keiki; Yamamoto, Makoto; Yamaguchi, Kentaro; Kohmoto, Shigeo
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 6 p. 1127 - 1131
