4-氯-2,6-二甲基-3-硝基吡啶合成路线 （共 12 条）
反应条件
1: ethanol / 5 h / Heating 2: H2 / 5percent Pd/C / aq. ethanol / 2327.2 Torr 3: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h 4: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1: 93 percent / triethylamine / propan-2-ol / 20 h / Heating
2: 98 percent / thionylchloride / CH2Cl2 / 2 h / Heating
3: 16 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Anagnostopulos, Hiristo; Bartlett, Robert R.; Elben, Ulrich; Stoll, Paul
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 227 - 232
