2-溴-3-氰基-6-甲基吡啶合成路线 （共 6 条）
反应条件
P2O5; anhydrous sodium hydrogen carbonate; sodium chloride; tetrabutylammomium bromide in water; toluene
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US6114524 A1, 2000 ;
反应条件
phosphoric acid; pyridin-2-yl hydrobromide; phosphorus oxytribromide in benzene 72 h; Heating;
参考文献
Victory, P.; Borrell, J. I.; Castejon, P.; Martinez-Teipel, B.; Vidal-Ferran, A.
Anales de Quimica, 1993 , vol. 89, p. 625 - 628
反应条件
1: With trifluorormethanesulfonic acid; lithium bromide in toluene T=20 - 40°C; 18.1667 h; 2: With sodium hydroxide in water; toluene T=5°C; pH=10;
参考文献
Maloney, Kevin M.; Nwakpuda, Emily; Kuethe, Jeffrey T.; Yin, Jingjun
Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5111 - 5114
反应条件
sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=25°C; 6 h; Inert atmosphere;
参考文献
Chelucci, Giorgio
Tetrahedron Letters, 2010 , vol. 51, # 12 p. 1562 - 1565
反应条件
1: With diisobutylaluminium hydride in toluene
T=-50°C; 2.5 h;
2: With sulfuric acid in tetrahydrofuran; toluene
T=20°C; 16 h;
参考文献
Robert, Nicolas; Hoarau, Christophe; Celanire, Sylvain; Ribereau, Pierre; Godard, Alain; Queguiner, Guy; Marsais, Francis
Tetrahedron, 2005 , vol. 61, # 19 p. 4569 - 4576
反应条件
ammonia in ethanol
T=130°C; 20 h;
参考文献
Chris Krueger; Madigan, Darold L.; Beno, David W.; Betebenner, David A.; Carrick, Robert; Green, Brian E.; He, Wenping; Liu, Dachun; Maring, Clarence J.; McDaniel, Keith F.; Mo, Hongmei; Molla, Akhteruzzaman; Motter, Christopher E.; Pilot-Matias, Tami J.; Tufano, Michael D.; Kempf, Dale J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2212 - 2215
