(3S-顺式)-(9CI)-八氢吡咯并[1,2-a]吡嗪-3-甲醇合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=65 - 68°C; 72 h;
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 11 p. 2389 - 2398
Tetrahedron Asymmetry, , vol. 7, # 7 p. 1999 - 2005
反应条件
1: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating 2: methanol / 110 h / 62 - 65 °C 3: 70 percent / LiAlH4 / tetrahydrofuran / 72 h / 65 - 68 °C View Scheme
参考文献
Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo
Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398
反应条件
1: 4-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 2: 4-methylmorpholine / CH2Cl2 / a) -15 deg C, 1 h, b) RT, 12 h 3: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating 4: methanol / 110 h / 62 - 65 °C 5: 70 percent / LiAlH4 / tetrahydrofuran / 72 h / 65 - 68 °C View Scheme
参考文献
Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo
Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398
