反应条件
1: thionyl chloride / tetrahydrofuran; dimethylformamide / 20 °C 2: tetra-n-butylammonium hydrogen sulfate, aq. NaHCO3 / CH2Cl2 / 16 h / Ambient temperature 3: trifluoroacetic acid (TFA) / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Alig; Edenhofer; Hadvary; Hurzeler; Knopp; Muller; Steiner; Trzeciak; Weller
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4393 - 4407