甲基 2-(三氟甲基)-6-吡啶羧酸合成路线 （共 3 条）
反应条件
triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate T=60°C; 17 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/131814 A2, 2009 ;
Location in patent: Page/Page column 45 ;
WO 2009/131814 A2
反应条件
in N,N-dimethyl-formamide T=80°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Mormino, Michael G.; Fier, Patrick S.; Hartwig, John F.
Organic Letters, 2014 , vol. 16, # 6 p. 1744 - 1747
反应条件
1: carbon dioxide; 2-trifluoromethylpyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in diethyl ether; hexane T=-75°C; 2 h; 2: diazomethane in diethyl ether Title compound not separated from byproducts;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1569 - 1575
