4-苄基-3-戊烯酸酰-1,3-噁唑烷-2-酮合成路线 （共 5 条）
反应条件
1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexanes T=-74 - -65°C; 0.5 h; 2: 4-pentenoic acid chloride in tetrahydrofuran; hexanes 19.1667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/127688 A2, 2007 ;
Location in patent: Page/Page column 35; 44-45 ;
反应条件
1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.166667 h; 2: 4-pentenoic acid chloride in tetrahydrofuran; hexanes T=-78 - 20°C; 1.5 h;
参考文献
Peng, Lee F.; Stanton, Benjamin Z.; Maloof, Nicole; Wang, Xiang; Schreiber, Stuart L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6319 - 6325
反应条件
1: 3-vinylpropionic acid With pivaloyl chloride; triethylamine in diethyl ether T=-78 - 0°C; 2: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78 - 0°C;
参考文献
Kerherve, Jennifer; Botuha, Candice; Dubois, Joelle
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 10 p. 2214 - 2222
反应条件
1: 3-vinylpropionic acid; pivaloyl chloride With triethylamine in tetrahydrofuran T=-78 - 0°C; 1 h; 2: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h;
参考文献
Hon, Yung-Son; Hsieh, Cheng-Han; Liu, Yu-Wei
Tetrahedron, 2005 , vol. 61, # 10 p. 2713 - 2723
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C;
参考文献
Zhou, Jian; Yang, Minmin; Akdag, Akin; Wang, Haisheng; Schneller, Stewart W.
Tetrahedron, 2008 , vol. 64, # 2 p. 433 - 438
