4-[2-(2-氨基-4,7-二氢-4-氧-3H-吡咯并[2,3-d]嘧啶-5-基)乙基]苯甲酸甲酯合成路线 （共 8 条）
反应条件
sodium hydroxide in water; acetonitrile
参考文献
WO2011/64256 A1, ;
Page/Page column 16-17 ;
反应条件
2: hydrogen / palladium on carbon 3: sodium tetrahydroborate 4: triethylamine / tetrahydrofuran 5: hydrogenchloride; acetic acid 6: sodium hydroxide / acetonitrile; water View Scheme
反应条件
1: hydrogenchloride; acetic acid 2: sodium hydroxide / acetonitrile; water View Scheme
反应条件
1: triethylamine / tetrahydrofuran 2: hydrogenchloride; acetic acid 3: sodium hydroxide / acetonitrile; water View Scheme
反应条件
sodium hydroxide in water; acetonitrile
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; ALBRECHT, Uwe, Jens; HELMBOLDT, Hannes; NIKOLAEV, Vsevolod, Valiervich
Patent: WO2011/64256 A1, 2011 ;
Location in patent: Page/Page column 16-17 ;
反应条件
2: hydrogen / palladium on carbon
3: sodium tetrahydroborate
4: triethylamine / tetrahydrofuran
5: hydrogenchloride; acetic acid
6: sodium hydroxide / acetonitrile; water
View Scheme
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; ALBRECHT, Uwe, Jens; HELMBOLDT, Hannes; NIKOLAEV, Vsevolod, Valiervich
Patent: WO2011/64256 A1, 2011 ;
反应条件
1: hydrogenchloride; acetic acid
2: sodium hydroxide / acetonitrile; water
View Scheme
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; ALBRECHT, Uwe, Jens; HELMBOLDT, Hannes; NIKOLAEV, Vsevolod, Valiervich
Patent: WO2011/64256 A1, 2011 ;
反应条件
1: triethylamine / tetrahydrofuran
2: hydrogenchloride; acetic acid
3: sodium hydroxide / acetonitrile; water
View Scheme
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; ALBRECHT, Uwe, Jens; HELMBOLDT, Hannes; NIKOLAEV, Vsevolod, Valiervich
Patent: WO2011/64256 A1, 2011 ;
