2-甲基-2-丙基4-({[(苄氧基)羰基]氨基}甲基)-1-哌啶羧酸酯合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2 h;
参考文献
VENTIRX PHARMACEUTICALS, INC.; ARRAY BIOPHARMA, INC.; HOWBERT, James, Jeffry; DIETSCH, Gregory; HERSHBERG, Robert; BURGESS, Laurence, E.; LYSSIKATOS, Joseph, P.; NEWHOUSE, Brad; YANG, Hong, Woon
Patent: WO2011/22508 A2, 2011 ;
Location in patent: Page/Page column 52; 53 ;
WO 2011/022508 A2
反应条件
titanium(IV) isopropylate T=120°C; 18 h;
参考文献
Shapiro, Gideon; Marzi, Martin
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7096 - 7097
参考文献
Merck and Co., Inc.
Patent: US6143750 A1, 2000 ;
US 6143750 A
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.
Patent: US2002/165241 A1, 2002 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 2.5 h; 2: With potassium carbonate in methanol; water; ethyl acetate 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/68739 A1, 2007 ;
Location in patent: Page/Page column 35 ;
WO 2007/068739 A1
