in methanol 24 h; Reflux;

lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide 1.) THF, 0 deg C, then reflux, 3 h ; 3 M H2SO4 added, reflux overnight, 2.) solvent evaporated, reflux, 6 h, 3.) 190 deg C, 10 min, then 230 deg C, 30 min ; double (13)C labelling; Yield given. Multistep reaction;

T=170 - 180°C;

View Scheme

暂无反应条件数据

n-butyllithium in tetrahydrofuran; hexane

in acetone

potassium tert-butylate in various solvent(s) T=0°C; 2 h;