2-(3-甲氧基苯基)环己酮合成路线 （共 13 条）
反应条件
potassium hydroxide in tetrahydrofuran; ethanol
参考文献
Tetrahedron, , vol. 29, p. 2183 - 2188
反应条件
1: 1.) sodamide / 1.) THF, reflux, 90 min, 2.) amb. temp., 16 h 2: 160 g / hydroxylamine hydrochloride, sodium hydroxide / methanol; H2O / 2 h / 40 °C View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
1: hexane / 1.75 h / Reflux
2: hydrogenchloride / water; methanol / 4 h / 0 - 20 °C
3: pyridine; trichlorophosphate / toluene / 1 h / Reflux
4: methanesulfonic acid; dl-methionine / 16 h
5: hydrogen / Raney Nickel / methanol / 12 h / 20 °C / 1500.15 Torr
View Scheme
参考文献
GRUeNENTHAL GMBH; HOLENZ, Joerg; BUSCHMANN, Helmut Heinrich
Patent: WO2011/147576 A1, 2011 ;
