N-(3-氨基丙基)-N-苄基-1,3-丙烷二胺合成路线 （共 9 条）
反应条件
hydrogen in methanol; water T=70°C; P=30003 Torr; 2 h;
参考文献
Beigi, Maryam; Ricken, Stefan; Mueller, Kai Sven; Koc, Fikret; Eilbracht, Peter
European Journal of Organic Chemistry, 2011 , # 8 p. 1482 - 1492
反应条件
1: 83 percent / NaI; Na2CO3 / acetonitrile / 5 h / Heating 2: 81 percent / aq. NaOH; H2 / Raney Ni / ethanol / 48 h / 1034.3 - 1551.44 Torr View Scheme
参考文献
Demillo, Violeta G.; Goulinet-Mateo, Florian; Kim, Jessica; Schols, Dominique; Vermeire, Kurt; Bell, Thomas W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5712 - 5721
反应条件
1: 68 percent / aq. NaHCO3 / 6 h / Heating 2: 81 percent / H2; aq. NaOH / Raney nickel / ethanol / 40 h / 2068.59 Torr View Scheme
参考文献
Demillo, Violeta G.; Goulinet-Mateo, Florian; Kim, Jessica; Schols, Dominique; Vermeire, Kurt; Bell, Thomas W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5712 - 5721
反应条件
hydrazine hydrate in ethanol 2 h; Heating;
参考文献
Fasseur, Dominique; Lacour, Sylvie; Guilard, Roger
Synthetic Communications, 1998 , vol. 28, # 2 p. 285 - 294
反应条件
1: 64 percent / 168 h / 110 °C 2: 60 percent / aluminum chloride, lithium aluminum hydride / diethyl ether / 72 h View Scheme
参考文献
Bergeron; Kline; Stolowich; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4524 - 4529
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Culf, Adrian S.; Melanson, Jennifer A.; Ouellette, Rodney J.; Briand, Glen G.
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3301 - 3304
反应条件
1: 83 percent / acetic acid / 1 h / Heating 2: 58 percent / K2CO3 / acetonitrile / 12 h / Heating 3: 85 percent / N2H4*H2O / ethanol / 2 h / Heating View Scheme
参考文献
Culf, Adrian S.; Melanson, Jennifer A.; Ouellette, Rodney J.; Briand, Glen G.
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3301 - 3304
反应条件
1: 58 percent / K2CO3 / acetonitrile / 12 h / Heating 2: 85 percent / N2H4*H2O / ethanol / 2 h / Heating View Scheme
参考文献
Fasseur, Dominique; Lacour, Sylvie; Guilard, Roger
Synthetic Communications, 1998 , vol. 28, # 2 p. 285 - 294
反应条件
1: triethylamine; potassium iodide / chloroform / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Culf, Adrian S.; Melanson, Jennifer A.; Ouellette, Rodney J.; Briand, Glen G.
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3301 - 3304
