2-甲基-2-丙基3-(叠氮基甲基)-1-哌啶羧酸酯合成路线 （共 6 条）
反应条件
sodium azide in N,N-dimethyl-formamide T=50°C; 24 h;
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: Et3N / ethyl acetate 2: NaN3 / dimethylformamide View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: tetrahydrofuran 2: Et3N / ethyl acetate 3: NaN3 / dimethylformamide View Scheme
参考文献
Sagara, Yufu; Mitsuya, Morihiro; Uchiyama, Minaho; Ogino, Yoshio; Kjmura, Toshifumi; Ohtake, Norikazu; Mase, Toshiaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 437 - 440
反应条件
1: LAH / tetrahydrofuran 2: tetrahydrofuran 3: Et3N / ethyl acetate 4: NaN3 / dimethylformamide View Scheme
参考文献
Sagara, Yufu; Mitsuya, Morihiro; Uchiyama, Minaho; Ogino, Yoshio; Kjmura, Toshifumi; Ohtake, Norikazu; Mase, Toshiaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 437 - 440
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Sagara, Yufu; Mitsuya, Morihiro; Uchiyama, Minaho; Ogino, Yoshio; Kjmura, Toshifumi; Ohtake, Norikazu; Mase, Toshiaki
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 437 - 440
反应条件
1: 98 percent / H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature 2: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
