2-苄基-1-氧代-2,8-二氮杂螺[4.5]癸烷-8-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: 86 percent / CHCl3 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT, 21 h View Scheme
参考文献
Cignarella, G.; Villa, S.; Barlocco, D.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120
反应条件
1: 58 percent / NaHSO3 / H2O / 0.25 h 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT, 21 h View Scheme
参考文献
Cignarella, G.; Villa, S.; Barlocco, D.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120
反应条件
lithium diisopropyl amide 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT, 21 h; Yield given. Multistep reaction;
参考文献
Cignarella, G.; Villa, S.; Barlocco, D.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120
