1: 2,6-di-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.5 h; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.333333 h;

1: With lithium diisopropyl amide in tetrahydrofuran; hexane 0.75 h; 2: With hydrogenchloride in diethyl ether T=-75°C;

1.1: 3 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -75 °C 2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.75 h 2.2: 72 percent / HCl / diethyl ether / -75 °C View Scheme

lithium diisopropyl amide 1.) hexane, -65 deg C, 2 h, 2.) THF, hexane, from -65 deg C to RT; Yield given. Multistep reaction;

oxygen