2-(2,6-二氟-3-吡啶基)-2-氧乙酸叔丁酯合成路线 （共 4 条）
反应条件
1: 2,6-di-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: di-tert-butyldicarbonate in tetrahydrofuran T=-78 - -20°C; 0.833333 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
LEXICON PHARMACEUTICALS, INC.
Patent: WO2008/67121 A2, 2008 ;
Location in patent: Page/Page column 76 ;
反应条件
lithium diisopropyl amide 1.) cyclohexane, -65 deg C, 2.) THF, cyclohexane, -65 deg C, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Shutske, Gregory M.; Roehr, Joachim E.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 789 - 795
反应条件
hydrazine hydrate; Ti(O-IPr)4 in dichloromethane
参考文献
Hoechst-Roussel Pharmaceuticals Incorporated
Patent: US5300498 A1, 1994 ;
US 5300498 A
反应条件
1: titanium(IV) isopropoxide, hydraziner hydrate / CH2Cl2 / 1 h 2: NaH / tetrahydrofuran / 0.33 h View Scheme
参考文献
Shutske, Gregory M.; Roehr, Joachim E.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 789 - 795
