4-甲氧基四氢吡喃-4-甲腈合成路线 （共 5 条）
反应条件
titanium tetrachloride in dichloromethane T=-78 - 20°C; Inert atmosphere;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2090570 A1, 2009 ;
Location in patent: Page/Page column 95 ;
EP 2090570 A1
反应条件
1: toluene sulfonic acid / methanol / 0.5 h / 80 °C / Sealed tube 2: tin(IV) chloride / dichloromethane / -70 - 20 °C View Scheme
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/101065 A2, 2012 ;
WO 2012/101065 A2
反应条件
1: toluene-4-sulfonic acid / methanol / 0.5 h / 80 °C 2: tin(IV) chloride / dichloromethane / -70 - 20 °C View Scheme
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
WO 2011/026917 A1
反应条件
1: With water; potassium hydroxide 4 h; Reflux; 2: With hydrogenchloride; water
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2090570 A1, 2009 ;
Location in patent: Page/Page column 95 ;
EP 2090570 A1
参考文献
Bird; Olivier
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 515 - 520
