1: 1.) LDA / 1.) THF, -60 deg C, 2 h, 2.) THF, 1 h 2: 33 percent / CH2Cl2 / 24 h / 20 °C 3: 76 percent / AlCl3 / CH2Cl2 / 0.17 h / 20 °C 4: 78 percent / KF, KHCO3, 30percent H2O2/H2O / tetrahydrofuran; methanol / 17 h / 20 °C 5: 70 percent / O2 / Irradiation View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) 5percent MeLi / 1.) HMPT, ether, 0 deg C, 15 min, 2.) HMPT, ether, THF, -78 deg C, 15 min<br />2: 95 percent / lithium diisopropylamide / tetrahydrofuran<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) 5percent MeLi / 1.) HMPT, ether, 0 deg C, 15 min, 2.) HMPT, ether, THF, -78 deg C, 15 min<br />2: 95 percent / lithium diisopropylamide / tetrahydrofuran<br /> <br /> &nbsp;