4-(氯甲基)-2-氟吡啶合成路线 （共 4 条）
反应条件
N-chloro-succinimide; dibenzoyl peroxide in tetrachloromethane
参考文献
SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1717229 A1, 2006 ;
Location in patent: Page/Page column 28-29 ;
反应条件
N-chloro-succinimide; acetic acid; dibenzoyl peroxide in acetonitrile Chlorination; 1.5 h; Heating;
参考文献
Earl, Richard A.; Zaczek, Robert; Teleha, Christopher A.; Fisher, Barbara N.; Maciag, Carla M.; Marynowski, Maria E.; Logue, Andrew R.; Tam, S. William; Tinker, William J.; Huang, Shiew-Mei; Chorvat, Robert J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4615 - 4622
反应条件
1: 9,10-dihydro-9-oxoanthracene With lithium tert-butylate in tetrahydrofuran T=15 - 30°C; Metallation; 2: 2-fluoro-pyridin-4-ylmethyl chloride in tetrahydrofuran T=40 - 50°C; Alkylation; Dimerization; Further stages.;
参考文献
Pesti; Huhn; Yin; Xing; Fortunak; Earl
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722
反应条件
potassium carbonate in water Hydrolysis; 2 h; Heating;
参考文献
Pesti; Huhn; Yin; Xing; Fortunak; Earl
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722
