(1R,2S,3S)-8-(3-氟丙基)-3-(4-碘苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯合成路线 （共 5 条）
反应条件
triethylamine in toluene Inert atmosphereReflux;
参考文献
GE HEALTHCARE LIMITED; WILLIAMS, Lorenzo; KEILEN, Gunnar; HAUGAN, Jarle Andre
Patent: WO2011/73256 A1, 2011 ;
Location in patent: Page/Page column 13 ;
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053
反应条件
1.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating 1.2: MeOH / 20 °C 2.1: KI; Et3N / ethanol / Heating View Scheme
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053
反应条件
1.1: I2; AgBF4 / methanol 2.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating 2.2: MeOH / 20 °C 3.1: KI; Et3N / ethanol / Heating View Scheme
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053
反应条件
1.1: diethyl ether 2.1: I2; AgBF4 / methanol 3.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating 3.2: MeOH / 20 °C 4.1: KI; Et3N / ethanol / Heating View Scheme
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053
