N-叔丁氧羰基-3-苯基-D-苯丙氨醇合成路线 （共 9 条）
反应条件
1: 2(S)-{N-[(R)-α-methylbenzyl]amino}-1,1-diphenyl-1,3-propanediol With hydrogen; palladium dihydroxide in formic acid T=20°C; P=5171.48 Torr; 6 h; 2: di-tert-butyl dicarbonate With sodium hydroxide in ethyl acetate 4 h;
参考文献
Chang, Jae-Won; Ha, Hyun-Joon; Park, Chan Sun; Kim, Min Sung; Lee, Won Koo
Heterocycles, 2002 , vol. 57, # 6 p. 1143 - 1148
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in ethyl acetate 2 h;
参考文献
Koskinen, Ari M. P.; Hassila, Heikki; Myllymaeki, Vesa T.; Rissanen, Karl
Tetrahedron Letters, 1995 , vol. 36, # 31 p. 5619 - 5622
反应条件
caesium carbonate in methanol
参考文献
Sibi, Mukund P.; Deshpande, Prasad K.; Loggia, Anthony J. La; Christensen, James W.
Tetrahedron Letters, 1995 , vol. 36, # 49 p. 8961 - 8964
反应条件
1.1: 91 percent / CH2Cl2 / 4 h / 20 °C 2.1: 96 percent / KOH / ethanol / 2 h / 20 °C 3.1: H2 / 20 percent Pd(OH)2/C / formic acid / 6 h / 20 °C / 5171.48 Torr 3.2: 78 percent / 1M aq. NaOH / ethyl acetate / 4 h View Scheme
参考文献
Heterocycles, , vol. 57, # 6 p. 1143 - 1148
反应条件
1.1: 96 percent / KOH / ethanol / 2 h / 20 °C 2.1: H2 / 20 percent Pd(OH)2/C / formic acid / 6 h / 20 °C / 5171.48 Torr 2.2: 78 percent / 1M aq. NaOH / ethyl acetate / 4 h View Scheme
参考文献
Heterocycles, , vol. 57, # 6 p. 1143 - 1148
反应条件
1: 95 percent / TEA / tetrahydrofuran 2: 88 percent / Cs2CO3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 49 p. 8961 - 8964
反应条件
1: 79 percent / Na / NH3 / 0.25 h 2: 95 percent / TEA / tetrahydrofuran 3: 88 percent / Cs2CO3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 49 p. 8961 - 8964
反应条件
T=0°C; Jones oxidation;
参考文献
Kanemasa; Adachi; Yamamoto; Wada
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 3 p. 681 - 687
反应条件
hydrogenchloride in tetrahydrofuran T=20°C; Hydrolysis; 24 h;
参考文献
Kanemasa; Adachi; Yamamoto; Wada
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 3 p. 681 - 687
