(+)-(2S,5R)-1-烯丙基-2,5-二甲基哌嗪合成路线 （共 4 条）
反应条件
1: 34.7 percent / acetone / 0.5 h / Heating 2: 33 percent / (+)-camphoric acid / acetone / resolution View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
参考文献
Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128
反应条件
1: 98 percent / aqueous NaHCO3 / CHCl3 / 4 h / 20 °C 2: 100 percent / hydrogen; glacial acetic acid / Pd/C / H2O / 3 h / Heating 3: 98 percent / CH2Cl2 / 0 - 20 °C 4: 97 percent / ammonium formate / Pd/C / methanol; H2O / 3 h / Heating View Scheme
参考文献
Janetka, James W.; Furness, M. Scott; Zhang, Xiaoyan; Coop, Andrew; Folk, John E.; Mattson, Mariena V.; Jacobson, Arthur E.; Rice, Kenner C.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3976 - 3980
反应条件
1: 98 percent / aqueous NaHCO3 / CHCl3 / 4 h / 20 °C 2: 100 percent / K2CO3 / 1,2-dichloro-ethane / 25 h / Heating 3: 98 percent / hydrogen / Pd/C / ethanol / 14 h 4: 95 percent / Na2CO3 / tetrahydrofuran / 20 °C 5: 82 percent / L-Selectride / tetrahydrofuran / 72 h / 20 °C View Scheme
参考文献
Janetka, James W.; Furness, M. Scott; Zhang, Xiaoyan; Coop, Andrew; Folk, John E.; Mattson, Mariena V.; Jacobson, Arthur E.; Rice, Kenner C.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3976 - 3980
