3-(4-氟苯基)-7-羟基-4H-1-苯并吡喃-4-酮合成路线 （共 9 条）
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; methanol T=20 - 60°C;
参考文献
Matin, Azadeh; Gavande, Navnath; Kim, Moon S.; Yang, Nancy X.; Salam, Noeris K.; Hanrahan, Jane R.; Roubin, Rebecca H.; Hibbs, David E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6835 - 6850
反应条件
morpholine in isopropyl alcohol T=80°C; 7 h;
参考文献
Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081
反应条件
boron trifluoride diethyl etherate; phosphorus trichoride T=50 - 60°C;
参考文献
Vasil'ev, S.A.; Golubushina, G.M.; Kabachnyi, V.I.; Luk'yanchikov, M.S.; Molchanov, G.I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 9 p. 641 - 645
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 9 p. 38 - 41
反应条件
1: boron trifluoride diethyl etherate / 5 h / 80 °C 2: 43.7 percent / morpholine / propan-2-ol / 7 h / 80 °C View Scheme
参考文献
Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081
反应条件
1: boron trifluoride diethyl etherate / 5 h / 80 °C 2: 43.7 percent / morpholine / propan-2-ol / 7 h / 80 °C View Scheme
参考文献
Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081
反应条件
1.1: pyridinium p-toluenesulfonate / 4 h / 20 °C / |Inert atmosphere 2.1: methanol / 3 h / 95 °C 2.2: 12 h / 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; ethanol; toluene / 1 h / 130 °C / |Inert atmosphere; |Microwave irradiation 4.1: toluene-4-sulfonic acid; hydrogenchloride / tetrahydrofuran; methanol / 1 h / 60 °C View Scheme
参考文献
Bepary, Sukumar; Youn, In Kwon; Lim, Hee-Jong; Lee, Ge Hyeong
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 9 p. 2829 - 2832
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; ethanol; toluene / 1 h / 130 °C / |Inert atmosphere; |Microwave irradiation 2: toluene-4-sulfonic acid; hydrogenchloride / tetrahydrofuran; methanol / 1 h / 60 °C View Scheme
参考文献
Bepary, Sukumar; Youn, In Kwon; Lim, Hee-Jong; Lee, Ge Hyeong
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 9 p. 2829 - 2832
反应条件
1.1: methanol / 3 h / 95 °C 1.2: 12 h / 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; ethanol; toluene / 1 h / 130 °C / |Inert atmosphere; |Microwave irradiation 3.1: toluene-4-sulfonic acid; hydrogenchloride / tetrahydrofuran; methanol / 1 h / 60 °C View Scheme
参考文献
Bepary, Sukumar; Youn, In Kwon; Lim, Hee-Jong; Lee, Ge Hyeong
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 9 p. 2829 - 2832
反应条件
potassium carbonate in acetone T=56°C;
参考文献
Vasil'ev, S.A.; Golubushina, G.M.; Kabachnyi, V.I.; Luk'yanchikov, M.S.; Molchanov, G.I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 9 p. 641 - 645
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 9 p. 38 - 41
