4,5-二氢-2-甲基-1,3-恶唑-4-羧酸甲酯合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
F2G LTD
Patent: WO2009/130481 A1, 2009 ;
Location in patent: Page/Page column 152 ;
反应条件
triethylamine in dichloromethane T=20°C; 18 h; Inert atmosphere;
参考文献
Hobson, Stephen J.; Parkin, Andrew; Marquez, Rodolfo
Organic Letters, 2008 , vol. 10, # 13 p. 2813 - 2816
反应条件
triethylamine in dichloromethane 16 h;
参考文献
Benoit, Georges-Emmanuel; Carey, John S.; Chapman, Alan M.; Chima, Ranjit; Hussain, Nigel; Popkin, Matthew E.; Roux, Guillaume; Tavassoli, Bahareh; Vaxelaire, Carine; Webb, Michael R.; Whatrup, David
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 88 - 95
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Schaeckel, Romy; Hinkelmann, Bettina; Sasse, Florenz; Kaiesse, Markus
Angewandte Chemie - International Edition, 2010 , vol. 49, # 9 p. 1619 - 1622
反应条件
in dichloromethane 24 h; Ambient temperature;
参考文献
Meyers; Tavares, Francis X.
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8207 - 8215
反应条件
trichloromonobromomethane; 1,5-diazabicyclolt;5.3.0gt;undecane in dichloromethane T=0°C; 6 h;
参考文献
Williams, David R.; Lowder, Patrick D.; Gu, Yu-Gui; Brooks, Dawn A.
Tetrahedron Letters, 1997 , vol. 38, # 3 p. 331 - 334
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichloromonobromomethane / dichloromethane / 6 h / 0 - 7 °C / |Large scale 2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / -5 °C View Scheme
参考文献
Benoit, Georges-Emmanuel; Carey, John S.; Chapman, Alan M.; Chima, Ranjit; Hussain, Nigel; Popkin, Matthew E.; Roux, Guillaume; Tavassoli, Bahareh; Vaxelaire, Carine; Webb, Michael R.; Whatrup, David
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 88 - 95
